Noninvasive preimplantation genetic testing: clinical application and progress
10.3760/cma.j.cn101441-20221001-00428
- VernacularTitle:无创PGT技术的临床应用及研究进展
- Author:
Qing ZHANG
1
;
Ping ZHOU
1
;
Yan HAO
1
;
Dan KUANG
1
;
Yiqi YIN
1
;
Yunxia CAO
1
Author Information
1. 安徽医科大学第一附属医院妇产科生殖医学中心，合肥 230032
- Publication Type:Journal Article
- Keywords:
Noninvasive preimplantation genetic testing;
Culture media of blastocysts;
Spent embryo culture media;
Free DNA
- From:
Chinese Journal of Reproduction and Contraception
2022;42(11):1152-1156
- CountryChina
- Language:Chinese
-
Abstract:
Preimplantation genetic testing (PGT) has been widely used today in assisted reproductive technology (ART). PGT can detect embryonic monogenic genetic diseases, chromosome structure and number abnormalities, and improve clinical outcomes in terms of embryo implantation, clinical pregnancy, and live birth rates. Biopsy procedure in PGT is 'invasive' for embryos and has high requirement for equipment and operators. With the discovery of free DNA for gene analysis in blastocyst fluid and embryo culture fluid and embryo culture fluid, a noninvasive PGT (NiPGT) becomes a potential alternative method. It has a broad application prospect in the field of assisted reproduction. Now we summarize the current application and research progress of NiPGT and analyze its effectiveness and limitations, to provide a basis for clinical applications.
