Study on related factors of futile reperfusion following mechanical thrombectomy for acute anterior circulation large vessel occlusion ischemic stroke within 6-24 hours
10.3969/j.issn.1002-0152.2025.07.003
- VernacularTitle:6～24小时急性前循环大血管闭塞缺血性脑卒中机械取栓术后无效再灌注的相关因素研究
- Author:
Runxiong LI
1
;
Weidong HU
;
Wangtao ZHONG
Author Information
1. 广东医科大学研究生院(东莞 523059);南方医科大学第十附属医院(东莞市人民医院)神经内科
- Publication Type:Journal Article
- Keywords:
Acute ischemic stroke;
Large vessel occlusion;
Mechanical thrombectomy;
Collateral circulation;
Futile recanalization;
Hypoperfusion index ratio;
Atrial fibrillation;
Prognosis
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(7):397-405
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To explore the clinical and imaging characteristics that related to futile recanalization after mechanical thrombectomy(MT)in patients with large vessel occlusion(LVO)in acute anterior circulation ischemic stroke within 6-24 h after the onset.Methods Retrospectively collected the data(MT-related data;clinical data)of patients with 6-24 h acute anterior circulation ischemic stroke with LVO who underwent MT treatment.Patients were divided into 2 groups:effectiv and ineffective reperfusion groups.Mild-to-moderate acute ischemic stroke group andsevere acute ischemic stroke group.Results A total of 115 patients(Grade mTICI 2b)were divided into two groups,of which 53 patients had effective reperfusion and 62 patients had ineffective reperfusion.The study found that the group with poor collateral circulation before thrombectomy(ASITN/SIR collateral circulation blood flow≤grade 2),those with atrial fibrillation,and those with a decrease in NIHSS by more than 4 points compared to the time of emergency department visit were statistically significant.The effective reperfusion group had a higher hypoperfusion intensity ratio(HIR)value,a higher hemorrhage conversion rate,a higher rate of early neurological deterioration,and a lower rate of good prognosis.Conclusions In the groups of patients with 6-24 h acute anterior circulation ischemic stroke LVO undergoing MT treatment,ASITN/SIR collateral circulation blood flow≤grade 2,HIR,Atrial fibrillation is highly related to futile recanalization.
