Puberty induction by autograft of cryopreserved ovarian tissue in a patient with β-thalassemia after hematopoietic stem cell transplantation: a case report and literature review
10.3760/cma.j.cn101441-20220730-00318
- VernacularTitle:造血干细胞移植术后的重度β地中海贫血患者自体移植冻融卵巢组织诱导青春期发育成功病例1例并文献复习
- Author:
Jingjie LI
1
;
Cong FANG
;
Manchao LI
;
Peng SUN
;
Dejuan WANG
;
Jianyun LIAO
;
Haitao ZENG
;
Panyu CHEN
;
Yun HU
;
Yingchun GUO
;
Yongfang LI
;
Xiaoyan LIANG
Author Information
1. 中山大学附属第六医院生殖医学中心，广州 510000
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Fertility preservation;
Ovarian tissue transplantation;
Thalassemia major
- From:
Chinese Journal of Reproduction and Contraception
2022;42(11):1187-1191
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the feasibility of autologous transplantation of frozen-thawed ovarian tissue to induce pubertal development in adolescent females.Methods:Before hematopoietic stem cell transplantation in patient with severe β-thalassemia, 11 pieces of ovarian tissue were frozen in the Center of Reproductive Medicine, the Sixth Affiliated Hospital of Sun Yat-sen University in 2019. The patient was diagnosed as premature ovarian failure after hematopoietic stem cell transplantation. There were no signs of puberty development and menarche. Orthotopic ovarian tissue transplantation was performed for the patient through laparoscopy, and a total of 5 pieces of ovarian tissue were transplanted on January 20, 2022. Postoperatively, we followed up the sex hormone levels, growth and development of the patients and menarche.Results:The patient developed menarche 5 months after ovarian transplantation. The levels of sex hormones showed that follicle-stimulating hormone and luteinizing hormone were significantly decreased, and estradiol levels were significantly increased, indicating that ovarian tissue transplantation was successful, and follicles had begun to recruit and develop. The patient's ultrasonography revealed a markedly enlarged uterus and a thickened endometrium. Antral follicles were detected in the left implantation site of pelvic cavity.Conclusion:Cryopreservation of ovarian tissue is recommended for fertility preservation in prepubertal children. Autologous frozen-thawed ovarian tissue transplantation can induce natural puberty development and restore the reproductive endocrine function in children with ovarian failure, delayed puberty development or even stagnation.
