Research progress on the Correlation between chitinase-3-like protein 1 and Alzheimer disease
10.3969/j.issn.1002-0152.2025.07.010
- VernacularTitle:几丁质酶3样蛋白1与阿尔茨海默病相关性研究进展
- Author:
Qu XU
1
;
Ming CAI
1
;
Qiang MA
1
Author Information
1. 大连大学附属中山医院神经内科(大连 116001)
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Chitinase-3-like protein1;
Reactive astrogliosis;
Neuroinflammation;
Biomarkers
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(7):444-448
- CountryChina
- Language:Chinese
-
Abstract:
Although chronic neuroinflammation has been established as one of core pathological hallmarks of Alzheimer disease(AD),its role in AD pathological mechanisms still remains elusive.The glia-derived inflammatory mediator chitinase-3-like protein 1(CHI3L1,also known as YKL-40)regulates key pathological processes including neuroinflammation,neuronal degeneration,and cell death.Evidence confirms that YKL-40 promotes the progression of AD core pathology through inhibiting amyloid plaque clearance and enhancing neuronal toxicity.Its expression levels is significantly correlated with early detection,disease severity,and clinical prognosis.A thorough understanding of the relationship between YKL-40 and AD not only deepen our insight into neuroinflammatory mechanisms in AD pathogenesis but also highlights its dual clinical applicability as a novel biomarker and therapeutic target,thereby providing an important direction for development of advanced diagnostic and treatment strategies for AD.
