Development status and application progress of oocyte in vitro maturation technology
10.3760/cma.j.cn101441-20220301-00090
- VernacularTitle:卵母细胞体外成熟技术发展现状及应用进展
- Author:
Jingyi HU
1
;
Guang YANG
1
;
Guidong YAO
1
Author Information
1. 郑州大学第一附属医院生殖医学中心，郑州 450052
- Publication Type:Journal Article
- Keywords:
Oocyte;
In vitro maturation;
Polycystic ovary syndrome;
Resistance ovarian syndrome;
Fertility preservation
- From:
Chinese Journal of Reproduction and Contraception
2023;43(7):763-767
- CountryChina
- Language:Chinese
-
Abstract:
In vitro maturation (IVM) technology is a reproductive technology that induces the maturation of cumulus-oocyte complexes to the MⅡ stage in vitro. Since the application of IVM technology, in order to improve the IVM rate of immature oocytes, the culture system has been continuously improved in the development, including the improvement of culture program and culture medium, and the optimization of culture environment, and a biphasic IVM protocol with higher oocyte maturation rate than conventional IVM protocol has been developed, with the effectively improvement of IVM clinical pregnancy rate. IVM technology has been widely used in patients with polycystic ovary syndrome to avoid ovarian hyperstimulation, and in patients with ovarian resistance syndrome who have ovarian reserve but do not respond to exogenous gonadotropins. Combined with a variety of fertility preservation technologies, it is also suitable for cancer patients who want fertility preservation. This view summarized the current development status and application progress of IVM technology, and makes a brief summary of the future direction of IVM.
