Progress in the study of gut microbiota and insulin resistant-polycystic ovary syndrome

VernacularTitle:肠道菌群与胰岛素抵抗型多囊卵巢综合征的研究进展
Author: Xiaoliu LU ¹ ; Shan XIANG ; Fang LIAN ; Chaofeng WEI ; Xin XIN
Author Information

1. 山东中医药大学第一临床医学院，济南　250011
Publication Type:Journal Article
Keywords: Polycystic ovary syndrome; Insulin resistance; Gut microbiota
From: Chinese Journal of Reproduction and Contraception 2023;43(2):209-212
CountryChina
Language:Chinese
Abstract: Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease, mostly associated with menstrual disorders, obesity, anovulation, etc., and 50%-70% with insulin resistance (IR), its pathogenesis is still unclear. Gut microbiota is a microecosystem involved in the occurrence and development of diseases as an environmental factor. A number of studies have shown that gut microbiota is closely related to the occurrence of PCOS. This paper summarizes the correlation between gut microbiota and IR-PCOS, and summarizes the mechanism of gut microbiota in IR-PCOS through low-grade inflammation, oxidative stress, DNA methylation and glucolipid metabolism, so as to provide new ideas for clinical diagnosis and treatment.