Research advances in treatment of cerebral ischemia-reperfusion injury by traditional Chinese medicine via modulating NLRP3 inflammasome-related signaling pathways

VernacularTitle:中药调控NLRP3炎症小体相关信号通路治疗CIRI的研究进展
Author: Yuxin WANG ¹ ; Pengyu PAN ; Tengyu ZHAO ; Yanyan ZHOU
Author Information

1. 黑龙江中医药大学,黑龙江哈尔滨 150040
Publication Type:Journal Article
Keywords: traditional Chinese medicine; nucleotide-binding oligomerization domain-like receptor protein 3; cerebral ischemia-reperfusion injury; inflammation
From: Chinese Journal of Pathophysiology 2025;41(8):1633-1638
CountryChina
Language:Chinese
Abstract: Cerebral ischemia-reperfusion injury(CIRI)is a pathological condition characterized by the aggra-vation of the secondary injury in the brain region previously deprived of blood supply upon the restoration of blood flow.nu-cleotide-binding oligomerization domain-like receptor protein 3(NLRP3),a pivotal inflammatory complex,plays an inte-gral role in the pathophysiology of CIRI.Its activation can instigate a robust inflammatory cascade,culminating in nerve cell death.In light of these insights,this paper reviews the structural characteristics,signaling transduction pathways,and mechanistic involvement of NLRP3 in CIRI.Additionally,the drug intervention strategies targeting inflammatory cor-puscles are discussed,with the aim of providing reference materials for the prevention and treatment of CIRI by traditional Chinese medicine.