Role of vascular microenvironment disorder in pathological process of cervical spondylosis of vertebral artery type
10.3969/j.issn.1000-4718.2025.08.018
- VernacularTitle:血管微环境紊乱在椎动脉型颈椎病病理进程中的作用
- Author:
Xiaoyu LIU
1
;
Min SONG
;
Yongjia SONG
;
Haonan WEN
;
Kai WANG
Author Information
1. 甘肃中医药大学中医临床学院,甘肃 兰州 730000
- Publication Type:Journal Article
- Keywords:
cervical spondylosis of vertebral artery type;
vascular microenvironment;
vascular homeostasis;
pathological mechanism
- From:
Chinese Journal of Pathophysiology
2025;41(8):1611-1618
- CountryChina
- Language:Chinese
-
Abstract:
Vascular homeostasis is a cornerstone for the normal operation of body tissues and organs,and it is closely related to the pathophysiological processes of cardiovascular and other systemic diseases.The maintenance of vas-cular homeostasis relies on a normal vascular microenvironment,and disturbances in this microenvironment are key factors in the development and progression of diseases.In recent years,significant progress has been made in the study of endo-thelial damage and hemodynamics in the pathogenesis of cervical spondylosis of vertebral artery type(CSA).However,these aspects represent only part of the vertebral artery microenvironment disorder and do not fully explain the pathogenesis of CSA.Therefore,this paper reviews endothelial dysfunction,abnormal vasomotor function of vascular smooth muscle,damage perception effects of the vascular adventitia,and matrix microenvironment disorders.The aim is to systematically elucidate the role of vascular microenvironment disorder in the pathological process of CSA,providing new perspectives for research into the disease's pathogenesis and therapeutic targets.
