Biological functions and pathophysiological significance of constitutive androstane receptor
10.3969/j.issn.1000-4718.2025.08.017
- VernacularTitle:组成型雄甾烷受体的生物学功能及其病理生理学意义
- Author:
Tingting JIANG
1
;
Nanping WANG
;
Lei XIAO
Author Information
1. 西安交通大学医学部基础医学院,陕西 西安 710061;大连医科大学医学科学研究院,辽宁 大连 116044
- Publication Type:Journal Article
- Keywords:
constitutive androstane receptor;
gene expression regulation;
metabolic diseases;
cancer;
cardio-vascular diseases
- From:
Chinese Journal of Pathophysiology
2025;41(8):1605-1610
- CountryChina
- Language:Chinese
-
Abstract:
Constitutive androstane receptor(CAR),a pivotal member of the nuclear receptor superfamily,is predominantly expressed in the liver and intestine.It plays a central role in orchestrating the metabolic clearance of xenobi-otics and endogenous metabolites.Unlike classical nuclear receptors,CAR exhibits constitutive transcriptional activity in the absence of ligands.In addition to its well-established function in regulating genes involved in drug metabolism and transport,accumulating evidence highlights its broader regulatory capacity in glucose and lipid homeostasis,bile acid me-tabolism,hormonal balance,and cellular proliferation.Furthermore,aberrant CAR signaling has been associated with the development and progression of multiple pathological conditions,including hepatic steatosis,diabetes,cancers,and car-diovascular diseases.This review summarizes the biological functions of CAR and its pathophysiological significance.
