Progress of Research on Antidepressants in Treatment of Inflammatory Bowel Disease

VernacularTitle:抗抑郁药在炎症性肠病治疗中的研究进展
Author: Fang LU ¹ ; Yong CHEN ; Zhenhua WANG ; Zhongde PAN
Author Information

1. 上海健康医学院附属嘉定区中心医院消化内科内镜室(201800)
Publication Type:Journal Article
Keywords: Inflammatory Bowel Disease; Depression; Antidepressants; Therapy
From: Chinese Journal of Gastroenterology 2024;29(6):363-369
CountryChina
Language:Chinese
Abstract: Inflammatory bowel disease(IBD)represents a group of chronic,nonspecific gastrointestinal disorders,primarily encompassing Crohn′s disease(CD)and ulcerative colitis(UC).The prevalence of comorbid depression is significantly higher among IBD patients compared to the general population.The administration of antidepressants in IBD patients with mood disorders can not only alleviate the IBD-related symptoms such as chronic pain and intestinal dysfunction,but also attenuate the inflammatory responses.These effects collectively contribute to improved prognosis and enhanced quality of life in patients with IBD.This article reviewed progress of research on antidepressants in the treatment of IBD,thereby providing references for the application of antidepressants in the treatment of IBD.