Research Progress on Function and Regulation of Gut-vascular Barrier
10.3969/j.issn.1008-7125.2024.06.007
- VernacularTitle:肠-血管屏障功能与调控的研究进展
- Author:
Fei WANG
1
;
Pengfei DU
;
Lei ZHANG
Author Information
1. 华中科技大学同济医学院第一临床学院(430022)
- Publication Type:Journal Article
- Keywords:
Gut-Vascular Barrier;
Influencing Factors;
Mechanisms;
Targeted Therapy
- From:
Chinese Journal of Gastroenterology
2024;29(6):357-362
- CountryChina
- Language:Chinese
-
Abstract:
The gut-vascular barrier(GVB)is a structural and functional unit constituted by microvascular endothelial cells,platelet-derived growth factor receptor β-positive pericytes,and glial fibrillary acidic protein-positive enteric glial cell end-feet.It plays a crucial role in preventing the translocation of gut microbiota,the entry of gut-derived macromolecules into the bloodstream,and maintaining the functional homeostasis in both the gut and the important extraintestinal organs such as liver,brain,and lung.This article reviewed the recent research progress on GVB,including the discovery of GVB,its structural and functional characteristics,the influencing factors and molecular basis of the integrity of GVB,and its role in related diseases,aiming to provide insights for the prevention and treatment of inflammation-related bowel disorders and damage to important extraintestinal organs.
