Progress in application of fecal microbiota transplantation in cardiovas-cular diseases
10.3969/j.issn.1000-4718.2025.08.019
- VernacularTitle:粪菌移植在心血管疾病中的应用进展
- Author:
Haijun MA
1
;
Jian LIANG
;
You YU
;
Rui YU
Author Information
1. 辽宁中医药大学,辽宁 沈阳 110847
- Publication Type:Journal Article
- Keywords:
gut microbiota;
fecal microbiota transplantation;
cardiovascular diseases
- From:
Chinese Journal of Pathophysiology
2025;41(8):1619-1625
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases pose a significant threat to the public health and healthcare systems in Chi-na.Their pathogenesis is complex and not yet fully elucidated.Increasing evidence suggests that the gut microbiota plays a crucial role in maintaining health and modulating disease progression.Dysbiosis of the gut microbiota has emerged as a key contributor to the development of cardiovascular diseases and has become a prominent focus of current biomedical re-search.Fecal microbiota transplantation,a direct and effective method for restoring gut microbial balance,has been ap-plied in clinical practice with continuously expanding indications,demonstrating the potential to become a novel therapeu-tic strategy for the prevention and treatment of cardiovascular diseases.This article reviews the technology of fecal microbi-ota transplantation,with a particular focus on its applications in major cardiovascular diseases,including atherosclerosis,myocardial infarction,heart failure,hypertension,atrial fibrillation,and myocarditis.It also outlines the potential mecha-nisms through which fecal microbiota transplantation may exert its therapeutic effects,aiming to provide a reference for clinical strategies in the prevention and management of cardiovascular diseases.
