Analysis of perinatal outcomes of ≤35 years old women with diminished ovarian reserve obtained live births in frozen-thawed embryo transfer cycles
10.3760/cma.j.cn101441-20210513-00213
- VernacularTitle:年龄≤35岁卵巢储备功能低下女性的冻融胚胎移植周期获得活产的围产期结局分析
- Author:
Mengjie WEI
1
;
Yan WEI
1
;
Guangen FENG
1
;
Qiuju CHEN
1
;
Weiran CHAI
1
Author Information
1. 上海交通大学医学院附属第九人民医院辅助生殖科，上海 200011
- Publication Type:Journal Article
- Keywords:
Fertilization in vitro;
Ovarian reserve;
Frozen-thawed embryo transfer;
Offspring
- From:
Chinese Journal of Reproduction and Contraception
2022;42(8):791-801
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of diminished ovarian reserve (DOR) on perinatal outcomes of young patients obtained live births through frozen-thawed embryo transfer (FET) cycles.Methods:In this retrospective cohort study, data of perinatal outcomes of patients who underwent FET and achieved pregnancy ≥24 weeks from January 2006 to December 2018 in Reproductive Medicine Department of Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine were analyzed. Patients were divided into non-DOR group ( n=14 342) and DOR group ( n=1292). The main outcome measure was the rate of low birth weight of newborns. The secondary outcome measures included infant gestational age, birth weight, gender, and incidence of congenital defects, neonatal death, and pregnancy complications. Univariate and multivariate logistic regression were applied to analyze the correlation between DOR and the outcomes of newborns and the rates of pregnancy complications. Results:There was no statistically significant difference in the birth weight of newborns between DOR group and non-DOR group in both singleton and twin pregnancies (all P>0.05). There were no significant differences in incidence of low birth weight, preterm birth, congenital defects, neonatal death, and pregnancy complications between the two groups (all P>0.05). After adjusting for relevant confounders by multivariate logistic regression analysis, DOR was not a risk factor for patients ≤35 years old to obtain singletons and twins with low birth weight through FET (singletons adjusted OR=0.97, 95% CI=0.69-1.34, P=0.831; twins adjusted OR=1.14, 95% CI=0.95-1.36, P=0.166). Conclusion:The birth outcomes of live births obtained by FET in DOR patients ≤35 years old were comparable to those obtained in non-DOR patients.
