A case report and literature review of repeated centrally located granular cytoplasm and ICSI fertilization failure
10.3760/cma.j.cn101441-20220801-00327
- VernacularTitle:反复卵母细胞胞质中央颗粒化并ICSI受精失败的1例病例报道并文献复习
- Author:
Hang DU
1
;
Xiaoxia LI
1
;
Xiaoguang SHAO
1
Author Information
1. 大连市妇女儿童医疗中心（集团）生殖与遗传中心，大连 116037
- Publication Type:Journal Article
- Keywords:
Oocyte;
Fertilization in vitro;
Sperm injections, intracytoplasmic;
Embryo transfer;
Centrally located granular cytoplasm
- From:
Chinese Journal of Reproduction and Contraception
2023;43(6):636-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the causes of centrally located granular cytoplasm (CLGC) in human oocytes during assisted fertilization and its effect on embryonic developmental potential.Methods:A case report was made on a patient in our center whose oocytes showed CLGC in intracytoplasmic sperm injection (ICSI) cycles, and the causes of CLGC formation and its impact on embryonic developmental potential were analyzed in combination with literature.Results:The oocytes obtained from this patient were all CLGC after using different ovulation induction programs and natural cycle programs, and normal fertilization was not completed after ICSI.Conclusion:CLGC has an important reference value for the evaluation of embryo quality and developmental potential. It is rare that all the oocytes of the patient are CLGC. When CLGC occurs, it may be possible to improve the occurrence of CLGC by asking whether there is a history of toxic exposure or adjusting the ovarian stimulation protocol, but it is not absolute. Attention should be paid to the evaluation of oocytes.
