Comparison of perinatal psychological distress between women conceiving spontaneously and through assisted reproductive technology: a longitudinal and prospective cohort study
10.3760/cma.j.cn101441-20211208-00547
- VernacularTitle:辅助生殖和自然受孕女性围产期心理健康的差异：一项前瞻性队列研究
- Author:
Yu WANG
1
;
Cheng LI
;
Han LIU
;
Chen ZHANG
;
Lei CHEN
;
Hefeng HUANG
;
Hong LI
;
Yanting WU
Author Information
1. 上海交通大学医学院附属国际和平妇幼保健院妇科内分泌与生殖医学科 上海市胚胎源性疾病重点实验室，上海 200030
- Publication Type:Journal Article
- Keywords:
Mental health;
Perinatal period;
Reproductive technology, assisted;
Spontaneous conception
- From:
Chinese Journal of Reproduction and Contraception
2023;43(3):269-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the perinatal mental health status of women conceived through assisted reproductive technology (ART) and women conceived naturally.Methods:In a prospective China National Birth Cohort study, 2 693 pregnant women were enrolled in the International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, School of Medicine from March 2017 to March 2021. They were divided into ART group ( n=733) and natural conception (NC group, n=1 960) according to the mode of conception. Mental health was assessed in the first trimester (<14 weeks), the second trimester (22-26 weeks), and the third trimester (30-34 weeks) as well as 6 weeks after delivery. Antenatally, mental health status was assessed by using the Center for Epidemiologic Studies Depression Scale (CESD), Self-rating Anxiety Scale (SAS), and Perceived Stress Scale (PSS). Postpartum depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS). Logistic regression was used to analyze maternal mental health related factors. Results:Logistic regression results showed that women in the ART group were less likely to experience depressive symptoms compared with those in the NC group in the first trimester (a OR=0.81, 95% CI: 0.66-0.99), the second trimester (a OR=0.73, 95% CI: 0.60-0.90), the third trimester (a OR=0.82, 95% CI: 0.68-1.00) and 6 weeks after delivery (a OR=0.57, 95% CI: 0.43-0.75). Meanwhile, women in the ART group felt significantly less stress during pregnancy than women in the NC group (the first trimester, P<0.001; the second trimester, P<0.001; the third trimester, P=0.001). However, the difference in women's anxiety symptoms during pregnancy was not found to be significant between the two groups (all P>0.05). Conclusion:Women who conceived through ART have lower risks of perinatal mental health problems than those who conceived spontaneously.
