Advances in 3D printed hydroxyapatite-collagen scaffolds in bone regeneration

VernacularTitle:三维打印羟基磷灰石-胶原蛋白支架在骨再生中的研究进展
Author: Ziyang CHENG ¹ ; Xiaoyan HAN ; Keming MAO ; Laikui LIU ; Weiwei LIANG
Author Information

1. 南京医科大学附属口腔医学院,江苏南京(210029)
Publication Type:Journal Article
Keywords: bone tissue engineering; 3D-printing; bioprinting
From: STOMATOLOGY 2025;45(1):75-80
CountryChina
Language:Chinese
Abstract: Bone tissue engineering(BTE)is expected to be used as an autologous bone graft substitute for bone defects,and in the se-lection of BTE scaffold materials,collagen(Col)and hydroxyapatite(HA)have attracted attention due to their unique biomimetic ad-vantages.Collagen/hydroxyapatite(CHA)composite scaffolds made by combining the two have been shown to have excellent biocompat-ibility and bone-enhancing potential in various in vitro,in vivo,and clinical studies.With the development of three-dimensional(3D)printing technology in the field of tissue engineering,bone scaffolds constructed using 3D printing methods have been shown to possess superior clinical potential.This review describes new advances in 3D printed CHA composite scaffolds and introduces the application of 3D printed CHA scaffolds in oral and maxillofacial bone regenerative repair.