The Role and Significance of Caveolin-1 Ubiquitination in Different Diseases
10.13865/j.cnki.cjbmb.2024.09.1137
- VernacularTitle:小窝蛋白1泛素化在不同疾病中的角色与意义
- Author:
Feng-Li HU
1
;
Peng-Fei WANG
1
;
Guo-Qiang GU
1
Author Information
1. 河北医科大学第二医院心内科,石家庄050000
- Publication Type:Journal Article
- Keywords:
caveolin-1 (Cav-1);
ubiquitination modification;
caveolae
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(12):1683-1690
- CountryChina
- Language:Chinese
-
Abstract:
Caveolin-1 (Cav-1) is the main component of caveolin,which can participate in physiological processes such as endocytosis,lipid transport and signal transduction.In recent years,more and more studies have found that the ubiquitination modification of Cav-1 can not only affect the level of Cav-1 it-self,but also cause conformational changes of interacting molecules by changing the protein structure,and then play various roles in different diseases.Cav-1 contains 12 lysine residues,of which 6 lysine res-idues in the N-terminal domain (5/26/30/39/47/57) are essential for the ubiquitination of Cav-1.The types and sites of ubiquitination of Cav-1 are different in diseases,and ubiquitination can be degraded by the ubiquitin-proteasome system and lysosomal pathway.In this paper,we reviewed the relevant studies of Cav-1 ubiquitination in respiratory,digestive,neurological,endocrine,mammary reproduction and other systemic diseases,and found that Cav-1 ubiquitination mainly involves tumor,inflammation,meta-bolic diseases and other disease processes.By reviewing the role of Cav-1 ubiquitination in different dis-ease models and cells,it is hoped to deepen the understanding of the physiological and pathophysiological significance of Cav-1 ubiquitination,and provide directions for possible future interventions.
