Study on the relationship between menopausal symptoms and everyday cognition in perimenopausal and postmenopausal women
10.3760/cma.j.cn101441-20201030-00596
- VernacularTitle:围绝经期和绝经后女性绝经症状与日常认知功能的相关性研究
- Author:
Wenjun HUANG
1
;
Lulu GENG
1
;
Susu JIANG
1
;
Changbin LI
1
;
Minfang TAO
1
Author Information
1. 上海交通大学附属第六人民医院妇产科，上海200030
- Publication Type:Journal Article
- Keywords:
Perimenopause;
Menopausal symptoms;
Everyday cognition;
Relationship
- From:
Chinese Journal of Reproduction and Contraception
2022;42(6):589-594
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the relationship between menopausal symptoms and everyday cognition in perimenopausal and postmenopausal women.Methods:A cross-sectional study was used to analyze the clinical data of 314 women who first visited the menopausal clinic of Department of Gynecology and Obstetrics of Shanghai Jiao Tong University Affiliated Sixth People's Hospital from October 2018 to October 2020. The modified Kupperman menopausal index (KMI) scale was used to assess the prevalence and severity of menopausal symptoms, and a short version of everyday cognition (ECog) scale was used to evaluate everyday cognition. Multiple linear regression was used to analyze the relationship between menopausal symptoms and everyday cognition in perimenopausal and postmenopausal women.Results:The ECog score of 314 patients was 1.50±0.49. The score of KMI was 12.67±7.88, 74.8% (235/314) of the patients had menopausal symptoms, and 34.7% (109/314) had moderate to severe menopausal symptoms. Compared with asymptomatic patients (ECog scores: 1.27±0.29), symptomatic patients had higher ECog scores (mild symptoms group: 1.48±0.47, P=0.005; moderate to severe symptoms group: 1.69±0.55, P<0.001) . Correlation analysis showed that the five symptoms of KMI (hot flashes/sweating, insomnia, irritability, melancholia and fatigue) were associated with the decline of everyday cognition ( P<0.001). Multiple linear regression analysis showed that the symptoms of hot flashes/sweating [ β=0.060, 95% confidence interval ( CI) =0.002-0.117, P=0.043], melancholia ( β=0.163, 95% CI=0.073-0.253, P<0.001 ) and fatigue ( β=0.138, 95% CI=0.071-0.205, P<0.001) were still associated with the decline of everyday cognition. Conclusion:The symptoms of hot flashes/sweating, melancholia and fatigue are independent risk factors for the decline of everyday cognition in perimenopausal and postmenopausal women.
