Research Progress of Mitochondrial Dependent Ferroptosis in Gastrointestinal Tumors
10.13865/j.cnki.cjbmb.2024.05.1431
- VernacularTitle:线粒体依赖性铁死亡在胃肠肿瘤中的作用及治疗
- Author:
Chen-Cong LV
1
;
Zai LUO
1
;
Chen HUANG
1
Author Information
1. 上海交通大学医学院附属第一人民医院胃肠外科,上海200080
- Publication Type:Journal Article
- Keywords:
mitochondria;
ferroptosis;
lipid peroxidation;
gastric cancer (GC);
colorectal cancer (CRC)
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(12):1649-1658
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a unique and novel form of regulated cell death characterized by iron depend-ence and lipid peroxidation.Ferroptosis can occur in multiple organelles,and more and more studies have found that mitochondria-dependent ferroptosis plays an important role in the progression of various diseases such as gastrointestinal tumors.Mitochondria,as the core of cellular substance and energy me-tabolism,can trigger mitochondria-dependent ferroptosis by producing reactive oxygen species through structures such as electron transport chains located in the inner membrane.It can also resist ferroptosis through antioxidant systems such as dihydroorotate dehydrogenase located on the outer side of the mito-chondrial inner membrane.Therefore,by targeting the molecules related to mitochondria-dependent fer-roptosis,it is expected to achieve accurate treatment of gastrointestinal tumors.This article reviews the morphological changes of mitochondria in ferroptosis,and summarizes the specific mechanisms of mito-chondria-dependent ferroptosis,including energy metabolism,lipid metabolism,iron metabolism,and other regulatory mechanisms involved.At the same time,the effect of mitochondria-dependent ferroptosis on the biological studies of gastrointestinal tumors and its potential value in the treatment of gastrointesti-nal tumors were also illustrated.This article reviews the specific mechanism of mitochondria-dependent ferroptosis and its application in the prognostic prediction and treatment in gastrointestinal tumors,aiming to provide potential targets for the prognosis prediction and treatment of gastrointestinal tumors.
