Effect of pregnancy outcome of the first IVF/ICSI embryo transfer cycle on the next frozen-thawed embryo transfer cycle
10.3760/cma.j.cn101441-20220319-00121
- VernacularTitle:IVF/ICSI首次移植妊娠结局对下次冻融胚胎移植妊娠结局的影响
- Author:
Qiqi XU
1
;
Kailun HU
1
;
Panpan CHEN
1
;
Chunxi ZHANG
1
;
Wei ZHAO
1
;
Yimin ZHU
1
;
Runju ZHANG
1
;
Lanfeng XING
1
;
Dan ZHANG
1
Author Information
1. 浙江大学医学院附属妇产科医院生殖内分泌科，杭州 310006
- Publication Type:Journal Article
- Keywords:
Infertility;
Frozen-thawed embryo transfer;
Pregnancy outcome;
Live birth
- From:
Chinese Journal of Reproduction and Contraception
2022;42(12):1226-1233
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of pregnancy outcome of the first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and embryo transfer cycle on the next frozen-thawed embryo transfer cycle. Methods:A retrospective cohort study was designed by collecting data from 6658 infertile patients in Department of Reproductive Endocrinology, Women's Hospital of Zhejiang University from January 2010 to December 2019. Two groups were included, the fresh embryo-frozen embryo group ( n=4310) and the frozen embryo-frozen embryo group ( n=2348), and each group was divided into four subgroups according to the pregnancy outcome of the first transfer cycle: non-pregnancy subgroup, biochemical pregnancy subgroup, pregnancy loss subgroup, and live birth subgroup. In each group, the live birth rate (LBR) of the second transfer cycle was compared among the four subgroups. Results:In the second transfer cycle of the fresh embryo-frozen embryo group, LBR in each subgroup was 31.3% (972/3109), 33.7% (92/273), 33.3% (169/507), and 39.2% (165/421), respectively. Compared with non-pregnancy subgroup, the difference of LBR in the live birth subgroup was statistically significant [after adjustment, a P<0.001, a OR(95% CI)=1.555(1.245-1.942)]. In the second transfer cycle of the frozen embryo-frozen embryo group, LBR in each subgroup was 37.3% (655/1754), 47.0% (79/168), 45.4% (122/269), and 44.6% (70/157), respectively. Compared with non-pregnancy subgroup, the differences of LBR in biochemical pregnancy subgroup, pregnancy loss subgroup and live birth subgroup were statistically significant [after adjustment, a P=0.018, a OR(95% CI)=1.471(1.069-2.026); a P=0.014, a OR(95% CI)=1.388 (1.069-1.802); a P=0.035, a OR(95% CI)=1.452(1.026-2.054)]. Conclusion:In the fresh embryo-frozen embryo group, live birth in the first transfer cycle is associated with increased LBR in the subsequent cycles, while in the frozen embryo-frozen embryo group, biochemical pregnancy, pregnancy loss, or live birth in the first transfer cycle are associated with increased LBR in the following cycles.
