Research progress on the model of decreased ovarian reserve in mice

VernacularTitle:卵巢储备功能下降小鼠模型研究进展
Author: Tianhong HUANG ¹ ; Fei YE ; Kun ZHANG ; Yan GONG
Author Information

1. 成都医学院，成都　610500
Publication Type:Journal Article
Keywords: Decreased ovarian reserve; Models; Animal; Mice; Cyclophosphamide
From: Chinese Journal of Reproduction and Contraception 2022;42(7):763-767
CountryChina
Language:Chinese
Abstract: Decreased ovarian reserve (DOR) impairs the physical and mental health of women. It is difficult to obtain the ovary of human for research due to ethical reason. Construction of animal model of DOR may handle the problem. Research on animal model of DOR is useful to explore the pathophysiology and treatment of DOR. There are several mouse models of DOR with its individual characteristics, including drug model (chemotherapeutic drugs, metabolic drugs, immunomodulators), radiation exposure model, genetic engineering model and environmental toxicant exposure model. The better mouse model of DOR is conducted by injection of cyclophosphamide, with the following advantages: simple, economic, efficient, effective, repeatable and controllable. In this paper, the principles and characteristics of commonly used mouse model of DOR were reviewed.