Effect of different intervals between oocyte retrieval and frozen-thawed embryo transfer in pregnancy outcome in patients with moderate and severe ovarian hyperstimulation syndrome
10.3760/cma.j.cn101441-20201126-00644
- VernacularTitle:中、重度卵巢过度刺激综合征患者取卵与解冻移植间隔时间对妊娠结局的影响
- Author:
Haixia DUAN
1
;
Juanzi SHI
;
Lijuan FAN
Author Information
1. 西北妇女儿童医院生殖妇科，西安 710000
- Publication Type:Journal Article
- Keywords:
Fertilization in vitro;
Embryo transfer;
Ovarian hyperstimulation syndrome;
Frozen-thawed embryo transfer;
Pregnancy outcome
- From:
Chinese Journal of Reproduction and Contraception
2022;42(7):724-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the pregnancy outcomes of different intervals between oocyte retrieval and frozen-thawed embryo transfer (FET) in moderate and severe ovarian hyperstimulation syndrome (OHSS) patients.Methods:Clinical data of infertile patients who underwent their first in vitro fertilization-embryo transfer (IVF-ET) and froze all their embryos for moderate or severe OHSS from January 2017 to December 2018 in the ART Center, Northwest Women's & Children's Hospital were analyzed retrospectively. All patients were divided into three groups according to the interval between oocyte retrieval and FET. Group A: one month interval; group B: two months interval; group C: the interval was three months or above. Main outcome was live birth rate; secondary outcomes included biochemical pregnancy rate, clinical pregnancy rate, implantation rate, ectopic pregnancy rate, miscarriage rate, preterm birth rate and birth defect rate. Chi square test was performed to compare the differences of the outcomes among the three groups. Results:The live birth rate of group B [70.27% (26/37)] was higher than that of group A [58.62% (17/29)] and group C [52.27% (23/44)], but the difference was not statistically significant ( P=0.667). The miscarriage rate of group A [0% (0/18)] was significantly lower than that of group C [25.81% (8/31), P=0.017]. There were no significant differences among the three groups in biochemical pregnancy rate, implantation rate, ectopic pregnancy rate, preterm birth rate and birth defect rate (all P>0.05). Conclusion:The interval between oocyte retrieval and FET in moderate and severe OHSS patients does not impact pregnancy outcome.
