Impact of antimicrobial volume-based procurement and classification manage-ment policy on the use of carbapenem antibiotics in Hunan Province
10.12138/j.issn.1671-9638.20256642
- VernacularTitle:湖南省带量采购和分级管理政策对碳青霉烯类抗生素利用的影响
- Author:
Zehua WU
1
;
Junyu CHEN
;
Linyong XU
;
Yuxing MING
;
Yusong ZHOU
;
Xun HUANG
;
Chenchao FU
;
Zhaohui WANG
;
Shikun LIU
;
Zuojun LI
Author Information
1. 中南大学湘雅三医院药学部,湖南长沙 410013
- Publication Type:Journal Article
- Keywords:
carbapenem antibiotics;
antimicrobial volume-based procurement;
antimicrobial classification manage-ment;
evaluation of drug utilization;
Mann-Kendall trend test;
interrupted time series analysis
- From:
Chinese Journal of Infection Control
2025;24(1):105-112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the impact of antimicrobial volume-based procurement(VBP)and classification management policy on the clinical use of carbapenem antibiotics.Methods Changing trend in defined daily doses(DDDs),procurement cost(Cost),defined daily dose cost(DDDc),and DDDs per 1 000 inhabitants daily(DID)of carbapenem antibiotics in all levels of medical institutions were analyzed by Mann-Kendall trend test.May 1,2020 was taken as the intervention cut-off point of VBP policy,September 2021 was as intervention cut-off point of cla-ssification management list.The impact of VBP and classification management policy on the clinical use of carbape-nem antibiotics were studied by interrupted time series analysis.Results After implementing VBP policy,the DDDs and DID of carbapenem antibiotics increased obviously,but the long-term trend didn't change significantly.Compared with before the implementation of the policy,the cost and DDDc of carbapenem antibiotics decreased im-mediately,the long-term trend of DDDc changed significantly,but the long-term trend of cost didn't change signifi-cantly.The DDDs and Cost of carbapenem antibiotics decreased immediately after the update of classification ma-nagement list,but the long-term downward trend was not significant,and DDDc presented a long-term upward trend.Conclusion VBP policy reduces the DDDc and short-term cost of carbapenem antibiotics,but its long-term impact on DDDs,cost and DID is limited.Classification management has limited impact on the use of carbapenem antibiotics in medical institutions.
