Effects of anti-Müllerian hormone levels on early pregnancy loss and cumulative pregnancy outcome in in vitro fertilization/intracytoplasmic sperm injection
10.3760/cma.j.cn101441-20211008-00449
- VernacularTitle:AMH水平对IVF/ICSI早期妊娠丢失及累积妊娠结局的影响
- Author:
Mengmeng TIAN
1
;
Lijun ZHANG
1
;
Yayi GAO
1
;
Hui LIU
1
;
Mingze DU
1
;
Bingnan REN
1
;
Xingling WANG
1
Author Information
1. 郑州大学第三附属医院生殖医学中心，郑州 450052
- Publication Type:Journal Article
- Keywords:
Anti-Müllerian hormone;
Fertilization, in vitro;
Sperm injections, intracytoplasmic;
Embryo loss;
Pregnancy outcome;
Oocytes;
Live birth
- From:
Chinese Journal of Reproduction and Contraception
2022;42(6):574-581
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of anti-Müllerian hormone (AMH) level on early pregnancy loss and cumulative pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), and whether AMH level can be used as an indicator to evaluate the quality of oocytes. Methods:A retrospective cohort analysis was performed on 3701 women undergoing their first oocyte retrieval for IVF/ICSI at the Reproductive Center of the Third Affiliated Hospital of Zhengzhou University from December 2015 to December 2019. According to the age, patients were divided into elderly group (≥35 years old) and younger group (<35 years old). References to the Bologna criteria and POSEIDON criteria, patients were divided into three groups: low AMH group (AMH≤1 μg/L), moderately low AMH group (1 μg/L0.05) whether in the elderly group or the younger group. The cumulative pregnancy rates were 61.9% (211/341), 66.0% (319/483), 69.3% (1219/1760), and the cumulative live birth rates were 50.1% (171/341), 57.8% (279/483), 57.1% (1005/1760) in low AMH group, moderately low AMH group and normal AMH group of the younger group, respectively,and there were statistical differences ( P=0.020, P=0.047). After adjusting for confounding factors, in the younger group, cumulative pregnancy rate and cumulative live birth rate in the low AMH group were lower than those in the normal AMH group ( OR=0.617, 95% CI=0.460-0.829, P=0.001; OR=0.660, 95% CI=0.496-0.878, P=0.004), the cumulative pregnancy rate and the cumulative live birth rate in the moderately low AMH group were lower than those in the normal AMH group, but there was no statistical difference (all P>0.05). There were no significant differences in cumulative pregnancy rate and cumulative live birth rate among the three groups with different AMH levels in the elderly group (all P>0.05). Conclusion:AMH is not associated with the incidence of early pregnancy loss during the their first oocyte retrieval in IVF/ICSI. AMH level is an independent factor affecting the cumulative pregnancy outcome in the younger group, the pregnancy outcome of women with AMH ≤1 μg/L decreased significantly. In the eldly women, AMH was not significantly associated with cumulative pregnancy outcome. AMH level may not be an indicator of oocyte quality.
