Effect of extracellular vesicles on embryo-endometrial crosstalk during embryo implantation
10.3760/cma.j.cn101441-20210810-00343
- VernacularTitle:细胞外囊泡对胚胎植入过程中胚胎-子宫内膜双向通讯的影响
- Author:
Fengli GUAN
1
;
Ying SUN
1
;
Huilan DU
1
Author Information
1. 河北中医学院，石家庄050200
- Publication Type:Journal Article
- Keywords:
Embryo implantation;
Endometrium;
Extracellular vesicles
- From:
Chinese Journal of Reproduction and Contraception
2022;42(10):1092-1096
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the rapid development of assisted reproductive technology has brought good news to infertility patients, but the current success rate of embryo implantation is low. The studies have confirmed that about 50% to 75% of pregnancy failures are due to abnormal embryo implantation. Embryo implantation is a key link in the establishment of a normal pregnancy. Impaired uterine-embryo crosstalk is the main reason for embryo implantation failure. Many studies have confirmed that extracellular vesicles (EVs), as a new method of intercellular communication, play an important role in the process of embryo implantation and can carry drugs as a potential treatment for female infertility. This article reviewed the role of EVs in preimplantation uterine-embryo crosstalk and its regulatory mechanism, in order to provide a theoretical basis for the treatment of infertility and repeated implantation failure patients.
