Research progress of maternal-fetal interface microenvironment in recurrent abortion
10.3760/cma.j.cn101441-20211008-00448
- VernacularTitle:母-胎界面微环境在复发性流产中的研究进展
- Author:
Dan FENG
1
;
Wenjing SHI
;
Qin YAN
;
Chunqing SUN
;
Xingyu BI
;
Xiuping ZHANG
;
Suming XU
;
Yaoqin WANG
;
Xueqing WU
Author Information
1. 山西医科大学，太原 030001
- Publication Type:Journal Article
- Keywords:
Recurrent spontaneous abortion;
Maternal-fetal interface;
Immune cells;
Trophoblast cell;
Decidual stromal cells
- From:
Chinese Journal of Reproduction and Contraception
2022;42(5):518-523
- CountryChina
- Language:Chinese
-
Abstract:
Recurrent spontaneous abortion (RSA) is a common adverse pregnancy outcome in women of childbearing age and its etiology is complex and still not clear. The maternal-fetal interface microenvironment plays a key role in maintaining pregnancy. There are trophoblast cells, decidual stromal cells and immune cells in the maternal-fetal interface microenvironment. The abnormal number or function of these cells may induce changes in the microenvironment of maternal-fetal interface, such as spiral artery remodeling disorder and abnormal decidualization, which may lead to RSA. This review discusses the role and mechanism of these three main cells in RSA.
