Liver injury induced by Pushen capsules (蒲参胶囊)
10.3760/cma.j.cn114015-20231229-00948
- VernacularTitle:蒲参胶囊致肝损伤
- Author:
Ying GAO
1
;
Jicong FAN
;
Zhengrong LI
Author Information
1. 山东省郯城县第一人民医院药学部，郯城 276199
- Publication Type:Journal Article
- Keywords:
Drugs, Chinese herbal;
Chemical and drug induced liver injury;
Pushen capsules
- From:
Adverse Drug Reactions Journal
2024;26(11):695-697
- CountryChina
- Language:Chinese
-
Abstract:
A 55-year-old female patient received Pushen capsules 4 capsules orally thrice daily due to elevated triglyceride in physical examination. Three days after taking the medicine, the patient developed fatigue, anorexia, nausea, and vomiting, and 20 days later, she developed yellowish skin with itching, dark yellow urine, and clay-like stool. Laboratory tests showed alanine aminotransferase (ALT) 1 274 U/L, aspartate aminotransferase (AST) 946 U/L, alkaline phosphatase (ALP) 283 U/L, γ-glutamyltransferase (GGT) 271 U/L, total bilirubin (TBil) 126 μmol/L, direct bilirubin (DBil) 116 μmol/L. After eliminating viral hepatitis, autoimmune liver disease, fatty liver, liver cirrhosis, etc., the patient was diagnosed as having drug-induced liver injury, which was considered to be related to Pushen capsules. Pushen capsules was stopped and the treatments for liver protection and enzyme reduction were given. After 28 days, the above symptoms in the patient were significantly improved. Laboratory tests showed ALT 31 U/L, AST 38 U/L, ALP 98 U/L, GGT 110 U/L, TBil 17 μmol/L, and DBil 11 μmol/L. After consulting the literature, it was considered that the liver injury in the patient was probably related to the raw Polygonum multiflorum in Pushen capsules.
