Roles of miRNA-17-92 gene cluster in the pathogenesis of polycystic ovary syndrome

VernacularTitle:miRNA-17~92基因簇在多囊卵巢综合征发生发展中的作用研究进展
Author: Chunqing SUN ¹ ; Dan FENG ; Xingyu BI ; Yaoqin WANG ; Suming XU ; Xueqing WU
Author Information

1. 山西医科大学，太原　030001
Publication Type:Journal Article
Keywords: Polycystic ovary syndrome; miRNA-17-92 gene cluster; Granulosa cells
From: Chinese Journal of Reproduction and Contraception 2022;42(6):626-632
CountryChina
Language:Chinese
Abstract: Polycystic ovary syndrome (PCOS) is the most common endocrine disease in reproductive-aged women, which is characterized by polycystic ovary changes, hyperandrogenism and anovulation. A large number of studies have confirmed that miRNAs play an important role in the pathophysiology of PCOS. The miRNA-17-92 gene cluster is a family of miRNAs containing multiple cistron clusters. It was initially considered to be an oncogene, but it can trigger a variety of physiological and pathological processes in many diseases. In recent years, more and more evidence has showed that miRNA-17-92 gene cluster plays an important role in the development of PCOS. In this study, we reviewed the roles of miRNA-17-92 gene cluster in the development of PCOS.