Progress on the mechanism of connexin in embryo implantation and endometrial decidualization
10.3760/cma.j.cn101441-20200624-00355
- VernacularTitle:连接蛋白参与胚胎植入与子宫内膜蜕膜化作用机制的研究进展
- Author:
Fengli GUAN
1
;
Yuqian ZHANG
1
;
Jing CHEN
1
;
Huilan DU
1
Author Information
1. 河北中医学院，石家庄050200
- Publication Type:Journal Article
- Keywords:
Connexin protein;
Embryo implantation;
Decidualization;
Endometrial receptivity
- From:
Chinese Journal of Reproduction and Contraception
2022;42(2):199-203
- CountryChina
- Language:Chinese
-
Abstract:
At present, the success rate of embryo implantation is 30%-40%, of which 50%-75% of pregnancy failure originates from abnormal embryo implantation. Embryo implantation is a key link in the establishment of normal pregnancy. The main causes of embryo implantation failure are the damage of endometrial receptivity and the failure of endometrial stromal decidualization. Embryo implantation involves a range of signaling molecules and cytokines, and many studies have shown that connexin proteins are involved in the regulation of embryo implantation and endometrial decidualization. This article reviews the role of connexin in endometrial receptivity, decidualization, vascular remodeling, implantation and its regulatory mechanism, in order to provide theoretical basis for the treatment of infertility and repeated implantation failure patients, and provide new research targets for drug development.
