Effect of maternal depression in assisted reproductive techonology on offspring's premature delivery and low birth weight
10.3760/cma.j.cn101441-20210420-00179
- VernacularTitle:孕期抑郁对早产和低出生体质量影响的辅助生殖队列研究
- Author:
Junlan ZHOU
1
;
Xiaoqing PENG
;
Chunmei LIANG
;
Zhimin LU
;
Tingting JIANG
;
Yunxia CAO
Author Information
1. 安徽医科大学药学院，合肥 230032
- Publication Type:Journal Article
- Keywords:
Reproductive technology, assisted;
Antenatal depression;
Premature delivery;
Low birth weight
- From:
Chinese Journal of Reproduction and Contraception
2022;42(8):814-819
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the relationship between antenatal depression in mothers who received assisted reproductive techonology (ART) and premature birth and low birth weight.Methods:In this retrospective cohort study, 376 infertile women who successfully delivered single-child were recruited at the Reproductive Center, Department of Obstetrics and Gynecology of the First Affiliated Hospital of Anhui Medical University from May 2017 to December 2020. Binary logistic regression analysis model was used to analyze the association between pre-pregnancy depression, depression in the first, second and third trimesters and new onset depression during pregnancy with preterm delivery and low birth weight.Results:The detection rates of depression before pregnancy, in the first, second and third trimesters of pregnancy were 20.0% (75/376), 23.0% (83/363), 11.2% (41/366), 8.8% (31/354), respectively. There was no statistically significant association between depression in the pre-pregnancy, the first trimester and the second trimester and preterm delivery (all P>0.05). Depression in the third trimester ( RR=2.18, 95% CI=1.02-4.65, P=0.040) and new onset depression during pregnancy ( RR=2.03, 95% CI=1.01-4.05, P=0.046) were positively correlated with preterm delivery. The associations between pre-pregnancy depression, depression in the first, second and third trimesters, and new onset depression and low birth weight were not statistically significant (all P>0.05). Conclusion:Antenatal depression in the third trimester and new onset depression during pregnancy may be important risk factors for premature delivery, but there is no significant association between antenatal depression and low birth weight.
