Analysis of related factors of abortion in patients with polycystic ovary syndrome treated by in vitro fertilization and embryo transfer
10.3760/cma.j.cn101441-20200715-00395
- VernacularTitle:行体外受精-胚胎移植助孕的多囊卵巢综合征患者发生流产的相关因素分析
- Author:
Leizhen XIA
1
;
Qiongfang WU
1
;
Yan ZHAO
1
;
Yina HU
1
;
Lifeng TIAN
1
Author Information
1. 江西省妇幼保健院辅助生殖中心，南昌330006
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Fertilization in vitro;
Sperm injection, intracytoplasmic;
Abortion, spontaneous;
Twin pregnancy;
Interaction
- From:
Chinese Journal of Reproduction and Contraception
2022;42(2):142-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the risk factors of abortion and their interactions in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). Methods:A total of 3556 pregnant women who underwent IVF/ICSI-ET in Jiangxi Maternal and Child Health Hospital from January 2014 to June 2019 were analyzed, among which 889 women were diagnosed with PCOS (PCOS group) and 2667 women were diagnosed with infertility due to simple tube factors (control group). The clinical outcomes after pregnancy were compared between the two groups. Single and multiple logistic regression were used to find the influencing factors of abortion. Finally, subgroup analysis was conducted according to single/twin pregnancy and body mass index (BMI).Results:The abortion rate [11.81% (105/889)] and the late abortion rate [5.29% (47/889)] in PCOS group were significantly higher than those in control group [9.19% (245/2667), P=0.023; 3.64% (97/2667), P=0.031]. Univariate logistic regression showed that PCOS, twin pregnancy, high BMI, long duration of infertility were the risk factors of abortion. Multivariate logistics regression showed that the main risk factors affecting abortion rate were twin pregnancy, PCOS, and the interaction between the two factors. Subgroup analysis found that there were no differences in the early and late abortion rates between the two groups when women were singleton pregnancy. When women were twin pregnancy, the rate of early abortion was similar between the two groups, while the late abortion rate [8.58% (29/338)] in PCOS group was significantly higher than that in control group [3.11% (37/1188), P<0.001]. Conclusion:The rate of abortion is similar for PCOS women and simple tube factor infertility women when they were singleton pregnancy after IVF/ICSI-ET treatment. PCOS women have a similar rate of early abortion and higher rate of late abortion than simple tube factor infertility women when they were twin pregnancy.
