Research progress of antioxidant therapy in male infertility
10.3760/cma.j.cn101441-20210317-00133
- VernacularTitle:抗氧化制剂在男性不育中的研究概况
- Author:
Tao ZHOU
1
;
Weikang CHEN
;
Yupeng LIU
;
Zhigang WU
Author Information
1. 温州医科大学附属第一医院泌尿外科，温州 325000
- Publication Type:Journal Article
- Keywords:
Antioxidants;
Reactive oxygen species;
Oxidative stress;
Infertility, male
- From:
Chinese Journal of Reproduction and Contraception
2022;42(8):869-873
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, research on male infertility has focused on the effects of oxidative stress, reactive oxygen species (ROS) and antioxidants on the reproductive system. In physiological situations, an appropriate level of reactive oxygen species is required for sperm capacitation, acrosome reaction and fertilization of the egg. The imbalance of ROS production and scavenging system affects the activity, motility and survival rate of sperm by causing damage to the protein of sperm membrane protein, nucleic acid and mitochondrial DNA, resulting in infertility. The limited level of antioxidant defense and the single mechanism of DNA damage detection and repair, sperm are very susceptible to oxidative stress. Oral antioxidants are thought to improve sperm quality by reducing oxidative damage. This review expounds the research progress and prospects of domestic and foreign scholars in the treatment of male infertility using antioxidant agents in recent years, hoping to provide more ideas for the treatment of male infertility and solve some confusions in clinical treatment.
