Effect of GnRH-a dosage on IVF/ICSI clinical outcomes in luteal phase long protocol
10.3760/cma.j.cn101441-20200821-00456
- VernacularTitle:黄体期长效长方案促性腺激素释放激素激动剂剂量对IVF/ICSI临床结局的影响
- Author:
Huihui WANG
1
;
Qianying MA
;
Ying DENG
Author Information
1. 广州医科大学附属第三医院生殖医学中心，广州510150
- Publication Type:Journal Article
- Keywords:
Reproductive technology, assisted;
Superovulations;
Gonadotropin-releasing hormone
- From:
Chinese Journal of Reproduction and Contraception
2022;42(4):345-349
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of different dosages of gonadotropin-releasing hormone agonist (GnRH-a) on the clinical outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). Methods:In this prospective cohort study, we recruited patients who received IVF/ICSI-ET in Center for Reproductive Medicine, the Third Affiliated Hospital of Guangzhou Medical University from January 2018 to January 2019. A total of 273 patients were finally enrolled in the the study. We used the luteal phase long protocol in the controlled ovarian hyperstimulation program. Patients were divided into three groups according to the dosage of GnRH-a used: 1.0 mg, 0.8 mg and 0.5 mg. The basic clinical characteristics, controlled ovarian hyperstimulation, embryo transfer and offspring data were compared among the three groups.Results:There were no significant differences in basal clinical characteristics and offspring data (all P>0.05). The lower dosage of GnRH-a, the fewer days of ovarian stimulation, 0.5 mg group showed the least days of ovarian stimulation [(11.3±1.4) d], which was statistically significant from the other groups ( P<0.001). In addition, we also found a decreasing trend of total gonadotropin (Gn), a lower loss rate of the embryo and a higher live birth rate in 0.5 mg group, although the difference did not reach statistically significant (all P>0.05). On the contrast, in 1.0 mg group, the fertilization rate [71.6% (768/1073)] significantly decreased ( P=0.005), while the early abortion rate and the cancellation rate of the unavailable embryo cycles tended to increase but not statistically different (all P>0.05). Conclusion:0.5 mg GnRH-a can reduce the duration of ovarian stimulation and achieve good clinical outcomes, which may be a better dosage of down regulation.
