Effect of EmbryoGlue on the clinical outcomes in frozen-thawed embryo transfer based on propensity score matching
10.3760/cma.j.cn101441-20210520-00225
- VernacularTitle:基于倾向性评分匹配法探讨胚胎移植液EmbryoGlue对冻胚移植临床结局的影响
- Author:
Min HAO
1
;
Liang WANG
1
;
Xiang WANG
1
;
Wenjuan PANG
1
;
Ningxia SUN
1
Author Information
1. 海军军医大学第二附属医院生殖医学中心，上海 200003
- Publication Type:Journal Article
- Keywords:
EmbryoGlue;
Embryo transfer;
Clinical pregnancy rate
- From:
Chinese Journal of Reproduction and Contraception
2021;41(12):1103-1108
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of embryo transfer medium EmbryoGlue on the clinical outcomes of frozen-thawed embryo transfer.Methods:A retrospective cohort study was performed in 2848 cycles from patients undergoing frozen-thawed embryo transfer from January 1, 2016 to December 31, 2020 in the Reproductive Medicine Center, the Second Affiliated Hospital of Naval Medical University. According to the embryo transfer medium, those cycles were divided into two groups, the G-2 group including 1605 cycles and the EmbryoGlue group including 1243 cycles. Baseline characteristics and clinical outcomes were compared between the two groups. Propensity score matching (PSM) was performed on age, infertility factor, duration of infertility, endometrial preparation protocol, endometrial thickness, number of embryos transferred, number of good-quality embryos transferred and stage of embryo, then clinical outcomes were compared between the two groups again.Results:There were significant differences of the age [(33.46±4.66) years vs. (31.92±4.62) years, P<0.001], duration of infertility [(4.11±2.98) years vs. (3.36±2.60) years, P<0.001], endometrial thickness [(9.51±1.77) mm vs. (10.01±1.77) mm, P<0.001], number of embryos transferred (1.52±0.50 vs. 1.59±0.49, P=0.001), number of good-quality embryos transferred (1.28±0.64 vs. 1.47±0.57, P<0.001) between EmbryoGlue group and G-2 group before PSM. There was no statistically significant difference in the baseline characteristics between the two groups after PSM (all P>0.05). There were no statistically significant differences in biochemical pregnancy rate [61.1% (609/996) vs. 61.9% (617/996), P=0.713], clinical pregnancy rate [56.5% (563/996) vs. 57.0% (568/996), P=0.821], implantation rate [44.3% (674/1523) vs. 44.4% (691/1555), P=0.919], ectopic pregnancy rate [1.8% (10/563) vs. 1.8% (10/568), P=0.984] and abortion rate [16.9% (95/563) vs. 17.3% (98/568), P=0.865] between the two groups. Conclusion:Using EmbryoGlue as embryo transfer medium can obtain the same clinical outcomes as G-2, and EmbryoGlue cannot yet be considered to improve the clinical outcomes of frozen-thawed embryo transfer.
