Association of QRS duration on electrocardiogram,serum high density lipoprotein cholesterol level with cardiac function class in CHF patients
10.3969/j.issn.1008-0074.2025.04.04
- VernacularTitle:心电图QRS波时限、血清高密度脂蛋白胆固醇水平与CHF患者心功能分级的相关性分析
- Author:
Yin TU
1
;
Dong CHEN
1
;
Yan ZHANG
1
Author Information
1. 合肥市第三人民医院电生理科,安徽 合肥 230022
- Publication Type:Journal Article
- Keywords:
Heart failure;
Electrocardiography;
Cholesterol,HDL
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2025;34(4):455-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the association of QRS duration on electrocardiogram,serum high density lipopro-tein cholesterol(HDL-C)level with cardiac function class in patients with chronic heart failure(CHF).Methods:A total of 128 CHF patients admitted in the Third People's Hospital of Hefei between March 2021 and March 2024 were retrospectively selected.According to New York Heart Association(NYHA)classification,class Ⅱ～Ⅲ pa-tients were included in the mild-moderate group(n=92),and those of class Ⅳ were included in the severe group(n=36).The characteristics of QRS duration on electrocardiogram,blood lipid indexes and other clinical data were compared between the two groups.Spearman correlation test was used to analyze the association of QRS duration on electrocardiogram,HDL-C with cardiac function class in CHF patients.Multivariate Logistic regression analysis was performed to screen the factors associated with NYHA cardiac function class Ⅳ in CHF patients.Results:Compared to those in mild-moderate group,patients in severe group had significant higher QRS duration[(138.32±4.76)ms vs.(112.5±6.50)ms],and significant lower amplitude of QRS wave[(10.43±2.08)mV vs.(11.94±2.73)mV]and HDL-C level[(0.73±0.23)mmol/L vs.(1.20±0.20)mmol/L](P＜0.01 all).Spearman correlation analysis showed that cardiac function class was positively correlated with QRS duration(r=0.341),and negatively correlated with QRS wave amplitude and HDL-C level(r=-0.318,-0.335,P＜0.001 all)in CHF patients.Multivariate Logistic regression analysis showed that QRS duration was an independent risk factor for car-diac function class Ⅳ in CHF patients(OR=1.902,95％CI 1.371～2.639,P＜0.001),and HDL-C was an inde-pendent protective factor(OR=0.466,95％CI 0.273～0.798,P=0.006).Conclusion:Cardiac function class was closely associated with QRS duration and HDL-C level in CHF patients.Detection of the two indexes during clini-cal diagnosis or treatment may be beneficial to guide improving the prognosis.
