Seizures induced by combination of compound paracetamol and amantadine hydrochloride and aminophylline
10.3760/cma.j.cn114015-20220615-00527
- VernacularTitle:复方氨酚烷胺与氨茶碱联用致癫痫发作
- Author:
Lina ZHANG
1
;
Quan WANG
1
;
Jinfeng LI
1
;
Wei FANG
1
Author Information
1. 山东大学附属威海市立医院，威海 264200
- Publication Type:Journal Article
- Keywords:
Amantadine;
Aminophylline;
Caffeine;
Seizures;
Compound paracetamol and amantadine hydrochloride
- From:
Adverse Drug Reactions Journal
2023;25(9):572-574
- CountryChina
- Language:Chinese
-
Abstract:
A 66-year-old male patient with chronic bronchitis for more than 50 years received 0.1 g of aminophylline once or twice daily orally. Because of cough and runny nose, he took 1 compound paracetamol and amantadine hydrochloride tablet twice daily orally and added the dose of aminophylline to 0.2 g twice daily by himself. After 3 days of medication, the patient experienced sudden unconsciousness and limb convulsions without any triggering factors, with a total of 6 episodes. The results of brain magnetic resonance imaging and electroencephalography were normal. The possibility of intracranial infection could be ruled out through cerebrospinal fluid examination. Laboratory test showed creatine kinase (CK) 1 574 U/L. After 4 days of experimental treatments with haloperidol, piperacillin sodium, tazobactam sodium, budesonide suspension, etc., his CK was 217 U/L and no further seizures occurred. The patient′s seizures were considered to be related to combination of compound paracetamol and amantadine hydrochloride, and aminophylline.
