A study on the effect of autologous bone marrow nucleated cell transplantation in the treatment of ovarian dysfunction
10.3760/cma.j.cn101441-20210922-00420
- VernacularTitle:自体骨髓有核细胞移植治疗卵巢功能减退的效果研究
- Author:
Zhenzhen XIE
1
;
Muhetaer ALANUER
;
Rufei HUANG
;
Chunliu FAN
;
Guihua LI
;
Lijun ZHANG
;
Mei LU
;
Baochi LIU
;
Guanghong FANG
Author Information
1. 上海市生物医药技术研究院，国家卫生健康委员会计划生育药具重点实验室 200032
- Publication Type:Journal Article
- Keywords:
Bone marrow transplantation;
Stem cells;
Primary ovarian insufficiency;
Treatment outcome
- From:
Chinese Journal of Reproduction and Contraception
2021;41(12):1079-1085
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy of autologous bone marrow nucleated cell transplantation on ovarian dysfunction-related diseases.Methods:From September 2020 to August 2021, we conducted a before-after study in Shanghai Institute of Planned Parenthood Research Hospital and Shanghai New Hongqiao International Medical Center. A total of 28 patients with premature ovarian insufficiency, perimenopausal syndrome or repeated assisted reproduction failure were treated with ultrasound-guided autologous bone marrow nucleated cell transplantation into the ovaries. Clinical efficacy was evaluated by comparing the patients' self-reported symptoms, endometrial thickness, bilateral ovarian volume, the number of bilateral ovarian follicles, the maximum diameter of bilateral ovarian follicles, and the level of plasma estradiol, follicle-stimulating hormone (FSH), luteinizing hormone (LH), progesterone, prolactin, and testosterone.Results:After autologous bone marrow nucleated cell transplantation, the number of bilateral ovarian follicles and the maximum diameter of bilateral ovarian follicles statistically significantly increased by an average of 1.26±2.12 ( P=0.005) and (5.40±8.92) mm ( P=0.006), respectively. Endometrial thickness and bilateral ovarian volume increased after treatment although without statistically significance (all P>0.05). However, the ovarian volume, the number of follicles, and the maximum diameter of follicles with greater changes between the left and right sides of the treatment, were found to statistically significantly increase after treatment ( P=0.007, P<0.001, P=0.002). Besides, the levels of FSH, LH, progesterone, and prolactin decreased with no statistical significance (all P>0.05). The stratified analysis of disease types found that endometrial thickness, the number of bilateral ovarian follicles, and the maximum diameter of bilateral ovarian follicles after treatment tended to increase, but only the number of bilateral follicles and the maximum diameter of bilateral ovarian follicles in patients with perimenopausal syndrome showed statistical significance ( P=0.008, P=0.047). Conclusion:The present study suggested that autologous bone marrow nuclear cell therapy could improve ovarian function to some extent, and is expected to be a new treatment method for patients with premature ovarian insufficiency, perimenopausal syndrome, and repeated assisted reproduction failure. However, further studies with larger sample sizes are needed to corroborate the findings.
