Analysis of anaphylaxis caused by gonadorelin in children in gonadotropin-releasing hormone stimulation test
10.3760/cma.j.cn114015-20230116-00018
- VernacularTitle:促性腺激素释放激素激发试验中戈那瑞林致儿童严重过敏反应临床特征分析
- Author:
Yongxian JIANG
1
;
Xi YE
;
Aiyan LI
;
Bo QIN
;
Wenwen CHEN
;
Bingchen LANG
;
Gen LI
Author Information
1. 四川省妇幼保健院药学部，成都 610041
- Publication Type:Journal Article
- Keywords:
Puberty, precocious;
Gonadotropin-releasing hormone;
Anaphylaxis;
Drug- related side effects and adverse reactions;
Stimulation test;
Gonadorelin
- From:
Adverse Drug Reactions Journal
2023;25(9):538-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical characteristics of anaphylaxis caused by gonadorelin in children in gonadotropin-releasing hormone (GnRH) stimulation test.Methods:The research subjects were children aged ≤14 years who experienced anaphylaxis using gonadorelin in the Chengdu Adverse Reaction Center database from January 1, 2015 to December 31, 2021. The purpose of medication was GnRH stimulation test. Through the hospital information system, the children′s basic information, usage of gonadorelin, occurrence of severe allergic reactions, and treatments and outcomes of anaphylaxis were collected and retrospectively analyzed.Results:A total of 14 cases of anaphylaxis in children caused by gonadorelin in the GnRH stimulation test were collected, including 3 males and 14 females, with an age of (9±2) years. All 14 cases were evaluated with a score of ≥5 using the Naranjo evaluation method. The dose of gonadorelin in the 14 children was (2.55±0.09) μg/kg and the drug was all given by intravenously injection; anaphylaxis occurred in 4 children during the first GnRH stimulation test and in 10 children during the second GnRH stimulation test. The time from medication to anaphylaxis occurence was (6.0±3.5) minutes. The symptoms of anaphylaxis in 14 children were systemic allergic reactions, involving various systems throughout the body. All children had 3 or more types of systemic damage. After anaphylaxis occurrence, gonadorelin was discontinued in all 14 patients; 5 received intramuscular injection of adrenaline, 5 received intravenous injection of adrenaline, 1 received intravenous injection of isoprenaline and intramuscular injection of adrenaline, and 3 received intravenous injection of dexamethasone only. After treatments, all children were improved.Conclusions:Anaphylaxis caused by gonadorelin in children is a rare but severe adverse reaction, and the drug may have a possibility of cross allergy with GnRH analogues. Therefore, when diagnosing and treating precocious puberty in children, medication should be given under monitoring conditions.
