Roles and molecular mechanisms of long non-coding RNA in polycystic ovary syndrome
10.3760/cma.j.cn101441-20200716-00397
- VernacularTitle:长链非编码RNA在多囊卵巢综合征中的作用及分子机制
- Author:
Zhe SUN
1
;
Yun SUN
1
Author Information
1. 上海交通大学医学院附属仁济医院生殖医学中心，上海市辅助生殖与优生重点实验室，上海 200135
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Long non-coding RNA;
Anovulation;
Hyperandrogenism;
Insulin resistance
- From:
Chinese Journal of Reproduction and Contraception
2022;42(3):306-310
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome (PCOS) is a common reproductive endocrinopathy and metabolic disorder affecting 5%-20% of reproductive aged women and is the leading cause of anovulatory infertility. PCOS is highly complex and heterogeneous and the pathogenetic mechanism of it is yet unclear. Long non-coding RNA (lncRNA) are transcripts of more than 200 nucleotides which lack defined protein coding potential. LncRNA regulate cell growth, proliferation, differentiation, apoptosis in epigenetics, transcription and post-transcription levels. Recent studies indicated that lncRNA are dysregulated in blood, ovary granulosa cells, follicle fluid and uterine endometrium of PCOS patients. LncRNA are involved in anovulation, hyperandrogenism, insulin resistance and endometrial receptivity in PCOS and play pivotal roles in elucidating the pathogenesis of PCOS and providing potential biomarkers. In this review, we focused on roles and molecular mechanisms of lncRNA in PCOS.
