Association of ApoE,sSema4D,and CypA levels with unfavorable outcome in patients with chronic heart failure
10.3969/j.issn.1008-0074.2025.04.18
- VernacularTitle:ApoE、sSema4D及CypA水平与慢性心力衰竭患者预后不良的相关性
- Author:
Lan-yu ZHANG
1
;
Qiang-fu HU
;
Hang SHEN
;
Na LI
Author Information
1. 郑州大学第五附属医院心血管重症监护病房(CCU),河南郑州 450052
- Publication Type:Journal Article
- Keywords:
Heart failure;
Apolipoproteins E;
Semaphorins;
Cyclophilin A
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2025;34(4):533-536
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the association of apolipoprotein E(ApoE),soluble semaphoring 4D(sSema4D),and cyclophilin A(CypA)levels with unfavorable outcome in patients with chronic heart failure(CHF).Methods:We retrospectively enrolled 108 patients with CHF admitted in the Fifth Affiliated Hospital of Zhengzhou Universi-ty between March 2019 and March 2022.According to the outcome during 6-month follow-up,patients were di-vided into favorable outcome group(n=71)and unfavorable outcome group(n=37).ApoE,sSema4D and CypA levels were compared between the two groups,and multivariate Logistic regression was employed to identify the risk factors of unfavorable outcome within 6-month follow-up in CHF patients.Results:Compared to patients in the favorable outcome group,those in the unfavorable outcome group had significant higher proportion of NYHA classⅣ(59.46％vs.25.35％),serum creatinine[(80.74±3.89)μmol/L vs.(71.36±3.63)μmol/L],ApoE[(69.87±4.25)mg/L vs.(47.36±3.17)mg/L],sSema4D[(916.62±7.32)ng/L vs.(426.42±6.25)ng/L]and CypA[(6.74±1.32)ng/L vs.(4.38±0.72)ng/L](P＜0.001 all).Multivariate Logistic regression indicated that NY-HA class Ⅳ(OR=2.782,95％CI 1.166～6.636),serum creatinine(OR=29.893,95％CI 6.782～131.768),ApoE(OR=12.046,95％CI 4.694～30.913),sSema4D(OR=8.390,95％CI 2.260～31.146)and CypA(OR=6.486,95％CI 1.780～23.635)were independent risk factors for unfavorable outcome within 6-month follow-up in CHF patients(P＜0.05 or＜0.01).Conclusion:The levels of ApoE,sSema4D and CypA were closely associated with short-term unfavorable outcome in patients with chronic heart failure.
