A case of fertility preservation in a prepubertal patient with thalassemia major and review of relevant literature
10.3760/cma.j.cn101441-20200709-00388
- VernacularTitle:青春期前重度地中海贫血患者生育力保存病例1例并文献复习
- Author:
Jiayu LIN
1
;
Cong FANG
;
Jianyun LIAO
;
Haitao ZENG
;
Peng SUN
;
Tingting LI
;
Yajie CHANG
;
Yanfang WANG
;
Weixi CHEN
;
Xiaoyan LIANG
;
Jingjie LI
Author Information
1. 中山大学附属第六医院生殖医学中心，广州 510000
- Publication Type:Journal Article
- Keywords:
Beta-thalassemia;
Hematopoietic stem cell transplantation;
Fertility preservation;
In vitro oocyte maturation techniques;
Ovarian tissue cryopreserva
- From:
Chinese Journal of Reproduction and Contraception
2022;42(2):183-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the methods of fertility preservation in prepubertal patients with thalassemia major (TM), and to provide further data support for the fertility preservation in prepubertal patients with hematologic diseases.Methods:A case of a prepubertal patient with TM who required urgent hematopoietic stem cell transplantation (HSCT) receiving ovarian tissue cryopreservation (OTC) and in vitro maturation (IVM) to preserve fertility was reported, and the timing, the indications and strategies of fertility preservation in prepubertal girls with thalassemia were discussed in combination with related literature. Results:After ovarian tissue extraction, a total of 24 cumulus-oocyte complexes (COCs) and 11 ovarian cortex pieces were obtained through puncture and aspiration. After IVM for 48 h, a total of 9 M Ⅱ oocytes were frozen by vitrification. Conclusion:For the prepubertal girls facing HSCT urgently, cryopreserving ovarian tissue in combination with retrieving immature oocytes followed by IVM can preserve the fertility of patients to the greatest extent in a short period of time, as well as improve the therapeutic effect of fertility preservation in patients.
