Research progress on intestinal barrier in irritable bowel syndrome pathogenesis
10.3969/j.issn.1006-5725.2025.16.023
- VernacularTitle:肠道屏障在肠易激综合征发病机制中的研究进展
- Author:
Yue HE
1
;
Kexin CHENG
1
;
Yanqiu LI
1
;
Yujun HOU
1
;
Siyuan ZHOU
1
Author Information
1. 成都中医药大学针灸推拿学院(四川 成都 611137)
- Publication Type:Journal Article
- Keywords:
irritable bowel syndrome;
intestinal barrier;
mechanical barrier;
chemical barrier;
microbial barrier;
immune barrier;
research advances
- From:
The Journal of Practical Medicine
2025;41(16):2597-2603
- CountryChina
- Language:Chinese
-
Abstract:
Irritable bowel syndrome(IBS)is a prevalent functional gastrointestinal disorder characterized by a complex etiology involving multiple interacting factors.Accumulating evidence in recent years has indicated that intestinal barrier dysfunction may play a crucial role in the pathogenesis of IBS.This review systematically ex-amines the impact of intestinal barrier dysfunction on IBS,analyzing its associations with the mechanical,im-mune,chemical,and microbial components of the gut barrier,as well as current clinical treatment approaches.Moreover,this paper highlights the potential of intestinal barrier repair mechanisms as therapeutic targets,which may provide novel insights and directions for understanding the underlying pathophysiological mechanisms and de-veloping effective interventions for IBS.
