Adherence and its influencing factors of tegafur, gimeracil and oteracil potassium treatment in patients with gastric cancer after operation
10.3760/cma.j.cn114015-20230616-00443
- VernacularTitle:胃癌患者术后替吉奥治疗的依从性及其影响因素
- Author:
Kunpeng YU
1
;
Hongbin XU
1
Author Information
1. 南京中医药大学第二附属医院药学部，南京 210017
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Medication adherence;
Risk factors;
Tegafur, gimeracil and oteracil potassium
- From:
Adverse Drug Reactions Journal
2023;25(10):607-613
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the adherence and its influencing factors of tegafur, gimeracil and oteracil potassium (S-1) treatment in patients with tumor-node-metastasis (TNM) stage Ⅲ gastric cancer after operation.Methods:Medical records of adult patients with stage Ⅲ gastric cancer after operation in the Second Affiliated Hospital of Nanjing University of Chinese Medicine from October 2018 to April 2022 and treated with oral S-1 were collected, and the S-1 adherence and its related factors in these patients were retrospectively analyzed according to their S-1 treatment information. Good adherence was defined as completing 8 cycles of S-1 treatment within 186 days (14 days of continuous medication and 7 days of discontinuation as 1 cycle). The patients were divided into good and poor S-1 adherence groups. Univariate and multivariate logistic regression analysis were performed to analyze the factors affecting S-1 adherence of patients.Results:A total of 148 patients were entered in the study, including 116 males (78.4%) and 32 females (21.6%), with a median age of 67 (27-85) years. Sixty-nine patients (46.6%) completed ≥ 8 cycles of S-1 treatment within the set time and had good adherence; 79 (53.4%) patients had poor adherence. The reasons for interruption or failure to complete treatments as scheduled in the 79 patients were serious adverse reactions in 30 (38.0%) patients, refusal to treat in 27 (34.2%) patients, and poor curative effect in 22 (27.8%) patients. Univariate and multivariate logistic regression analysis showed that lack of or partial understanding of the disease [odds ratio ( OR)=5.368, 95% confidence interval ( CI): 1.488-19.370, P= 0.010; OR=3.393, 95% CI: 1.309-8.793, P=0.012], gastric cancer with a course of less than 1 year ( OR=10.214, 95% CI: 2.400-43.472, P=0.002), and TNM stage Ⅲa ( OR=3.879, 95% CI: 1.522-9.886, P=0.005) were the independent influencing factors of poor adherence to S-1 treatment in patients with gastric cancer. Conclusions:Less than half of the gastric cancer patients with stage Ⅲ after operation had good adherence to S-1 treatment. Insufficient understanding of the disease, short duration of gastric cancer, and TNM stage Ⅲa were independent influencing factors for poor adherence to S-1 treatment in gastric cancer patients. Increasing patients′ understanding of the disease and strengthening patient education may be important strategies to improve S-1 treatment compliance.
