Correlation analysis of plasma cortisol levels with fertility stress and pregnancy outcome in patients with IVF/ICSI
10.3760/cma.j.cn101441-20200623-00354
- VernacularTitle:血浆皮质醇水平与IVF/ICSI患者生育压力及妊娠结局相关性分析
- Author:
Yu TIAN
1
;
Chanyu ZHANG
1
Author Information
1. 重庆医科大学附属第二医院妇产科生殖医学中心，重庆400000
- Publication Type:Journal Article
- Keywords:
Infertility;
Fertility stress;
Plasma cortisol
- From:
Chinese Journal of Reproduction and Contraception
2022;42(1):30-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between fertility stress and plasma cortisol level, the correlation between fertility stress and plasma cortisol level and pregnancy outcome.Methods:This experiment is a case-control study. Convenience sampling method was used to select infertility women assisted by in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) in the Department of Reproductive Medicine, Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Chongqing Medical University between March 2019 and October 2019. A cross-sectional survey was conducted. The patients were divided into pregnancy and non-pregnancy groups and general data survey was conducted on the study subjects, and the fertility problem inventory (FPI) scale was adopted. A fertility stress assessment was performed and fasting plasma cortisol levels were measured in the morning before transplantation during the investigation. The plasma cortisol level before transplantation and the morning of the transplantation day were measured, and their pregnancy outcomes were followed up. Logistic regression analysis was used to determine the factors affecting pregnancy outcomes. Results:During the investigation, a total of 169 subjects underwent embryo transfer. There were 80 patients in pregnancy group and 89 patients in non-pregnancy group. There was no statistically significant difference in demographic and clinical characteristics between the two groups at baseline (all P>0.05). A total of 320 questionnaires were issued during the study period, and 291 valid questionnaires were recovered. The Spearman correlation analysis showed that plasma cortisol was positively correlated ( r=0.234, P<0.001) with fertility stress. Regression analysis showed that plasma cortisol on the day of transplantation was an independent factor affecting pregnancy outcome ( OR=1.002, 95％ CI=1.001-1.004, P=0.003). Conclusion:The level of plasma cortisol can reflect the fertility pressure of infertile patients, the content of plasma cortisol on the day of transplantation is an independent influencing factor of pregnancy outcome. With the increase of the content of plasma cortisol, the possibility of pregnancy decreases.
