Dual-energy CT combined with apparent diffusion coefficient value of brain metastases in predicting epidermal growth factor receptor mutation in lung adenocarcinoma
10.3969/j.issn.1002-1671.2025.08.009
- VernacularTitle:双能量CT联合脑转移瘤表观扩散系数值预测肺腺癌表皮生长因子受体突变
- Author:
Liping FENG
1
;
Xiangfa WANG
;
Qinxia SONG
;
Xiang HU
;
Feng CHEN
Author Information
1. 皖南医学院,安徽 芜湖 241000;安庆市立医院医学影像科,安徽 安庆 246003
- Publication Type:Journal Article
- Keywords:
dual-energy computed tomography;
apparent diffusion coefficient;
lung adenocarcinoma;
epidermal growth factor recep-tor;
brain metastases
- From:
Journal of Practical Radiology
2025;41(8):1294-1298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the value of the multi-parameter imaging of dual-energy computed tomography(DECT)combined with apparent diffusion coefficient(ADC)value of brain metastases in predicting lung adenocarcinoma with epidermal growth factor receptor(EGFR)gene mutation.Methods The DECT and MRI parameters of 90 patients with lung adenocarcinoma and brain metastases were collected.DECT parameters included normalized iodine concentrations in the arterial and venous phases(N1CA,NICV)and slope of the energy spectrum curves in the arterial and venous phases(kA,kv).The MRI parameters of brain metastases included ADC and relative ADC(rADC)of solid area,necrotic area,and peritumoral edema.Predictive model were constructed for EGFR gene mutation according to the parameters above.Results NICV,kv,ADC and rADC of solid area and peritumoral edema in the EGFR positive group were higher than those in the EGFR negative group,which had statistical significances(P＜0.05).Model1 and model2 were established by combining DECT or MRI parameters,while model3 was established by combining DECT and MRI parameters,which had the best predictive efficiency for EGFR gene mutation,with an area under the curve(AUC)of 0.846.Conclusion The predictive model combining DECT parameters with ADC value of brain metastases can improve the prediction efficiency of EGFR gene mutation in advanced lung adenocarcinoma.
