Levels of systemic and maternal-fetal interface oxidative stress in women with early pregnancy loss
10.3760/cma.j.cn101441-20200529-00317
- VernacularTitle:早期妊娠丢失患者全身性和母-胎界面的氧化应激水平研究
- Author:
Xian GONG
1
;
Jianmei WANG
1
;
Li SUN
1
;
Xiaopei LI
1
;
Yujuan ZHANG
1
Author Information
1. 天津医科大学第二医院计划生育科 300211
- Publication Type:Journal Article
- Keywords:
Abortion, missed;
Abortion, spontaneous;
Oxidative stress;
Serum;
Chorionic villi;
Lipid peroxidation;
Antioxidant capacity
- From:
Chinese Journal of Reproduction and Contraception
2021;41(7):631-637
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the correlation between systemic and local (at the maternal-fetal interface) oxidative stress in women with early pregnancy and the influencing factors of indicators, and to explore the associations between early pregnancy loss (EPL) and biomarkers of lipid peroxidation and total antioxidant capacity (T-AOC).Methods:A case-control study was performed. From December 2017 to July 2018, cases of EPL and controls of normal early pregnant women requesting induced abortions due to unintended pregnancies were recruited in the Family Planning Department of the Second Hospital of Tianjin Medical University. The levels of malondialdehyde (MDA) and T-AOC in serum of 103 participants and chorionic villous tissue of 60 participants in each group were measured. The influencing factors and the correlations between the levels of each biomarker in serum and villous were analyzed. The differences in the levels of each biomarker between the two groups were compared.Results:The levels of MDA and T-AOC in villi of case group and control group were both positively correlated with their serum markers, their correlation coefficients were r=0.744, P<0.001; r=0.312, P=0.015; r=0.712, P<0.001; r=0.650, P<0.001, respectively. Except for villus MDA in case group, serum and villus MDA and T-AOC increased with the increasing of gestational days in both groups. For each additional week of gestation in case group, serum MDA increased by 8.3% ( P=0.005), serum T-AOC increased by 4.2% ( P=0.002), villus T-AOC increased by 2.6% ( P=0.010), all of which were statistically significant; in control group, the serum MDA, serum T-AOC, villus MDA and villus T-AOC increased by 11.3% ( P=0.004), 5.4% ( P=0.007), 18.7% ( P=0.017) and 8.4% ( P=0.009) respectively for each additional week of gestation. After adjusting the gestational days, the serum T-AOC of the case group was 13.4% lower than that of control group ( P<0.001), the villus T-AOC was 33.7% lower than that of control group ( P<0.001), while the villus MDA was 30.1% higher than that of control group ( P=0.012). The serum MDA of the two groups had no statistic significance. Conclusion:The status of systemic oxidative stress is synchronized with that in the maternal-fetal interface in early pregnant women. Gestational age is an important factor affecting oxidative stress in serum and villous. EPL is associated with the reduction of systemic and maternal-fetal interface antioxidant capacity and maternal-fetal interface lipid peroxidation damage.
