Research progress on ubiquitin regulation function of TRAF6 and pathogenesis of rheumatoid arthritis
10.3969/j.issn.1000-484X.2025.02.043
- VernacularTitle:TRAF6泛素化调控功能与类风湿关节炎发病机制的研究进展
- Author:
Xiaona ZHANG
1
;
Xiaozheng DU
;
Bo YUAN
;
Fuxin LI
;
Limei LIU
Author Information
1. 甘肃中医药大学,兰州 730000
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
TRAF6;
Ubiquitin;
Signal pathway
- From:
Chinese Journal of Immunology
2025;41(2):510-512,后插1-后插2
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is a common autoimmune disease with synovitis as core pathological manifestation,with strong injury and high disability rate,which can not be cured completely at present.Recent studies have shown that tumor necro-sis factor receptor-related factor 6(TRAF6),as a ubiquitin ligase E3,plays a key role in autoimmune diseases and inflammatory diseases through a variety of pathways.This article reviews structure,function,ubiquitin regulation of TRAF6 and research progress of pathogenesis of RA.
