Clinical outcome analysis of patients with indented zona pellucida oocytes
10.3760/cma.j.cn101441-20210308-00110
- VernacularTitle:蜡样透明带卵母细胞患者临床助孕结局分析
- Author:
Hui MENG
1
;
Juan DONG
1
;
Le HAN
1
;
Meng XIA
1
;
Jiayin LIU
1
;
Lingbo CAI
1
Author Information
1. 南京医科大学第一附属医院生殖医学中心，生殖医学国家重点实验室，南京 210029
- Publication Type:Journal Article
- Keywords:
Sperm injections, intracytoplasmic;
Embryonic development;
Indented zona pellucida oocytes;
Cumulative pregnancy rate
- From:
Chinese Journal of Reproduction and Contraception
2022;42(7):729-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the difference of embryological and clinical outcomes between the oocytes with indented zona pellucida and normal morphology.Methods:A retrospective cohort study was conducted on 93 cycles treated with intracytoplasmic sperm injection (ICSI) in the Clinical Reproductive Medicine Center of the First Affiliated Hospital of Nanjing Medical University from January 2015 to December 2019. According to the morphology of oocytes and the methods of fertilization, the cycles were divided into three groups, normal oocytes with traditional ICSI group (group A, n=52), indented zona pellucida oocytes with traditional ICSI group (group B, n=30), and indented zona pellucida oocytes with rescue ICSI group (group C, n=11). Laboratory and clinical results were compared among the three groups. Results:There were no differences in oocytes retrieved rate, normal fertility rate, clinical pregnancy rate and implantation rate among the three groups (all P>0.05). The good-quality embryo rate in groups A [62.50% (250/400)] and B [59.07% (114/193)] was significantly higher than that in group C [40.85% (29/71); P=0.001, P=0.006] and blastocyst formation rate in group A [64.78% (160/247)] was significantly higher than that in group C [37.14% (13/35), P=0.002]. Otherwise, the abortion rate in group A [2.44% (1/41)] was significantly lower than that in groups B and C [21.05% (4/19), P=0.031; 44.44% (4/9), P=0.002] and the cumulative pregnancy rate in group A [82.69% (43/52)] was comparatively higher than that in groups B and C [56.67% (17/30), P=0.009; 45.45% (5/11), P=0.014]. Conclusion:Traditional ICSI insemination of the indented pellucida oocytes showed the similar results of good-quality embryo rate and blastocyst formation rate with that of normal oocytes, but the overall clinical outcome was lower than that of normal oocytes. Abnormal oocytes of zona pellucida should be inseminated by ICSI directly, which can obtain better clinical outcome.
