Research progress on mechanism of monomeric saponins in Chinese herbal medicine in anti-tumor immunity
10.3969/j.issn.1000-484X.2025.02.041
- VernacularTitle:中药单体皂苷类调控免疫细胞抗肿瘤作用机制的研究进展
- Author:
Mingyang HE
1
;
Chengzhi WANG
;
Xiaoqing ZHANG
;
Dongdong LI
;
Peimin LIU
Author Information
1. 河南中医药大学第二附属医院,郑州 450002
- Publication Type:Journal Article
- Keywords:
Saponins;
Immune cells;
Anti tumor;
Research progress
- From:
Chinese Journal of Immunology
2025;41(2):495-502
- CountryChina
- Language:Chinese
-
Abstract:
The incidence and mortality rates of malignant tumors continue to rise,which posing a serious threat to the physical and mental health of the global population,and becoming a significant scientific problem in urgent need of resolution.Tumor immuno-therapy,as a novel anti-tumor treatment,optimizes the treatment modalities for tumors.Currently,combination of immunotherapy with chemotherapy and targeted therapy has shown promising results in anti-tumor treatment.Traditional Chinese medicine is widely used in comprehensive anti-tumor treatments,demonstrating significant effectiveness and distinct advantages.Among them,monomeric saponins in Chinese herbal medicine exhibit remarkable anti-tumor effects with the notable advantages of high efficiency and low tox-icity.This has made them a focal point of research for many oncologists.Studies have revealed that a large number of monomeric sapo-nins from Chinese herbal medicine can directly or indirectly affect the functions of immune cells by regulating the innate immune sys-tem,adaptive immune system,and related immune cell factors.This enhances the immune cytotoxicity against tumor cells,thereby better exerting the anti-tumor immune effects.This paper summarizes the research findings on the anti-tumor effects of monomeric sapo-nins in recent years.It elaborates on the specific mechanisms by which monomeric saponins from Chinese herbal medicine regulate im-mune cells to exert anti-tumor effects.The aim of this paper is to provide new research perspectives for tumor immunotherapy,further harness the crucial role of traditional Chinese medicine in anti-tumor treatment,and propel the modernization of traditional Chinese medicine.
