Research progress of PD-1 regulating type 2 innate lymphocytes in different diseases
10.3969/j.issn.1000-484X.2025.02.038
- VernacularTitle:PD-1调控2型固有淋巴细胞在不同疾病中的研究进展
- Author:
Chunyao LIU
1
;
Dengrong ZHANG
;
Tingting BU
;
Zhenjie LUO
;
Xianping LONG
;
Song WANG
Author Information
1. 遵义医科大学附属医院急诊科,遵义 563000
- Publication Type:Journal Article
- Keywords:
PD-1;
ILC2s;
Cytokines;
Immunosuppression
- From:
Chinese Journal of Immunology
2025;41(2):479-483
- CountryChina
- Language:Chinese
-
Abstract:
Immune disorders play a vital role in the tumors,infections and allergic diseases.As a co-inhibitory molecule that has attracted much attention in recent years,programmed cell death protein 1(PD-1)can participate in immunomodulation in various immune diseases by inhibiting the proliferation and activation of type 2 innate lymphoid cells(ILC2s).ILC2s is a newly discovered subgroup of immune cell families,which is involved in tumor immunity,anti-parasitic infection and tissue damage repair by secreting type 2 cytokines.PD-1 is a major immunosuppressive molecule that can regulate the different immunomodulatory effects of ILC2s in different immune diseases.This article reviews the role and mechanism of PD-1 in regulating ILC2s in different diseases.
